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treespot compound profile visualization tool  (DiscoverX corporation)

 
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    DiscoverX corporation treespot compound profile visualization tool
    Structural and biochemical characterization of ASN007 (A) Molecular structure of ASN007, MW = 473. (B) Dose-response curves of ERK1/2 inhibitors (ASN007 or SCH772894) in a homogeneous time-resolved fluorescence (HTRF)-based ERK1/2 enzymatic activity assay. (C) Kinome tree dendrogram showing the biochemical kinase profiling assay (KinaseProfiler, Eurofiler), which measures the kinase inhibitory activity of ASN007 in a radiometric enzymatic assay in a panel of 335 purified kinases. Hit kinases reported are marked with a red circle and the size of the circle indicates the relative potency of ASN007 for each kinase. ERK1/2 kinases are illustrated by a blue circle. Green dots indicate kinases against which ASN007 does not have significant activity at 1 μM. The dendrogram was generated using the web tool <t>TREESpot,</t> provided by DiscoverX. (D) IC 50 values (nM) for ASN007 against the top 22 kinases, which showed >75% inhibition at 1 μμM, identified from the primary kinome screening. (E) Dose-dependent effect of ASN007 treatment on phosphorylation of ERK1/2 targets. Representative western blot analysis shows inhibition of RSK1 (Ser380) phosphorylation after 4h of ASN007 treatment in a colorectal adenocarcinoma cell line, HT-29. (F) Dose-response curve of ASN007 inhibition of RSK phosphorylation in the human colon cancer HT-29 BRAF V600E mutant cell line, measured by an ELISA test.
    Treespot Compound Profile Visualization Tool, supplied by DiscoverX corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/treespot+compound+profile+visualization+tool/pmc08324497-152-0-6?v=DiscoverX+corporation
    Average 90 stars, based on 1 article reviews
    treespot compound profile visualization tool - by Bioz Stars, 2026-07
    90/100 stars

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    1) Product Images from "ASN007 is a selective ERK1/2 inhibitor with preferential activity against RAS-and RAF-mutant tumors"

    Article Title: ASN007 is a selective ERK1/2 inhibitor with preferential activity against RAS-and RAF-mutant tumors

    Journal: Cell Reports Medicine

    doi: 10.1016/j.xcrm.2021.100350

    Structural and biochemical characterization of ASN007 (A) Molecular structure of ASN007, MW = 473. (B) Dose-response curves of ERK1/2 inhibitors (ASN007 or SCH772894) in a homogeneous time-resolved fluorescence (HTRF)-based ERK1/2 enzymatic activity assay. (C) Kinome tree dendrogram showing the biochemical kinase profiling assay (KinaseProfiler, Eurofiler), which measures the kinase inhibitory activity of ASN007 in a radiometric enzymatic assay in a panel of 335 purified kinases. Hit kinases reported are marked with a red circle and the size of the circle indicates the relative potency of ASN007 for each kinase. ERK1/2 kinases are illustrated by a blue circle. Green dots indicate kinases against which ASN007 does not have significant activity at 1 μM. The dendrogram was generated using the web tool TREESpot, provided by DiscoverX. (D) IC 50 values (nM) for ASN007 against the top 22 kinases, which showed >75% inhibition at 1 μμM, identified from the primary kinome screening. (E) Dose-dependent effect of ASN007 treatment on phosphorylation of ERK1/2 targets. Representative western blot analysis shows inhibition of RSK1 (Ser380) phosphorylation after 4h of ASN007 treatment in a colorectal adenocarcinoma cell line, HT-29. (F) Dose-response curve of ASN007 inhibition of RSK phosphorylation in the human colon cancer HT-29 BRAF V600E mutant cell line, measured by an ELISA test.
    Figure Legend Snippet: Structural and biochemical characterization of ASN007 (A) Molecular structure of ASN007, MW = 473. (B) Dose-response curves of ERK1/2 inhibitors (ASN007 or SCH772894) in a homogeneous time-resolved fluorescence (HTRF)-based ERK1/2 enzymatic activity assay. (C) Kinome tree dendrogram showing the biochemical kinase profiling assay (KinaseProfiler, Eurofiler), which measures the kinase inhibitory activity of ASN007 in a radiometric enzymatic assay in a panel of 335 purified kinases. Hit kinases reported are marked with a red circle and the size of the circle indicates the relative potency of ASN007 for each kinase. ERK1/2 kinases are illustrated by a blue circle. Green dots indicate kinases against which ASN007 does not have significant activity at 1 μM. The dendrogram was generated using the web tool TREESpot, provided by DiscoverX. (D) IC 50 values (nM) for ASN007 against the top 22 kinases, which showed >75% inhibition at 1 μμM, identified from the primary kinome screening. (E) Dose-dependent effect of ASN007 treatment on phosphorylation of ERK1/2 targets. Representative western blot analysis shows inhibition of RSK1 (Ser380) phosphorylation after 4h of ASN007 treatment in a colorectal adenocarcinoma cell line, HT-29. (F) Dose-response curve of ASN007 inhibition of RSK phosphorylation in the human colon cancer HT-29 BRAF V600E mutant cell line, measured by an ELISA test.

    Techniques Used: Fluorescence, Enzyme Activity Assay, Activity Assay, Enzymatic Assay, Purification, Generated, Inhibition, Phospho-proteomics, Western Blot, Mutagenesis, Enzyme-linked Immunosorbent Assay


    Figure Legend Snippet:

    Techniques Used: Plasmid Preparation, Recombinant, Proliferation Assay, Software



    Similar Products

    treespot compound profile visualization tool  (DiscoverX corporation)
    90
    DiscoverX corporation treespot compound profile visualization tool
    Structural and biochemical characterization of ASN007 (A) Molecular structure of ASN007, MW = 473. (B) Dose-response curves of ERK1/2 inhibitors (ASN007 or SCH772894) in a homogeneous time-resolved fluorescence (HTRF)-based ERK1/2 enzymatic activity assay. (C) Kinome tree dendrogram showing the biochemical kinase profiling assay (KinaseProfiler, Eurofiler), which measures the kinase inhibitory activity of ASN007 in a radiometric enzymatic assay in a panel of 335 purified kinases. Hit kinases reported are marked with a red circle and the size of the circle indicates the relative potency of ASN007 for each kinase. ERK1/2 kinases are illustrated by a blue circle. Green dots indicate kinases against which ASN007 does not have significant activity at 1 μM. The dendrogram was generated using the web tool <t>TREESpot,</t> provided by DiscoverX. (D) IC 50 values (nM) for ASN007 against the top 22 kinases, which showed >75% inhibition at 1 μμM, identified from the primary kinome screening. (E) Dose-dependent effect of ASN007 treatment on phosphorylation of ERK1/2 targets. Representative western blot analysis shows inhibition of RSK1 (Ser380) phosphorylation after 4h of ASN007 treatment in a colorectal adenocarcinoma cell line, HT-29. (F) Dose-response curve of ASN007 inhibition of RSK phosphorylation in the human colon cancer HT-29 BRAF V600E mutant cell line, measured by an ELISA test.
    Treespot Compound Profile Visualization Tool, supplied by DiscoverX corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/treespot+compound+profile+visualization+tool/pmc08324497-152-0-6?v=DiscoverX+corporation
    Average 90 stars, based on 1 article reviews
    treespot compound profile visualization tool - by Bioz Stars, 2026-07
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    Structural and biochemical characterization of ASN007 (A) Molecular structure of ASN007, MW = 473. (B) Dose-response curves of ERK1/2 inhibitors (ASN007 or SCH772894) in a homogeneous time-resolved fluorescence (HTRF)-based ERK1/2 enzymatic activity assay. (C) Kinome tree dendrogram showing the biochemical kinase profiling assay (KinaseProfiler, Eurofiler), which measures the kinase inhibitory activity of ASN007 in a radiometric enzymatic assay in a panel of 335 purified kinases. Hit kinases reported are marked with a red circle and the size of the circle indicates the relative potency of ASN007 for each kinase. ERK1/2 kinases are illustrated by a blue circle. Green dots indicate kinases against which ASN007 does not have significant activity at 1 μM. The dendrogram was generated using the web tool TREESpot, provided by DiscoverX. (D) IC 50 values (nM) for ASN007 against the top 22 kinases, which showed >75% inhibition at 1 μμM, identified from the primary kinome screening. (E) Dose-dependent effect of ASN007 treatment on phosphorylation of ERK1/2 targets. Representative western blot analysis shows inhibition of RSK1 (Ser380) phosphorylation after 4h of ASN007 treatment in a colorectal adenocarcinoma cell line, HT-29. (F) Dose-response curve of ASN007 inhibition of RSK phosphorylation in the human colon cancer HT-29 BRAF V600E mutant cell line, measured by an ELISA test.

    Journal: Cell Reports Medicine

    Article Title: ASN007 is a selective ERK1/2 inhibitor with preferential activity against RAS-and RAF-mutant tumors

    doi: 10.1016/j.xcrm.2021.100350

    Figure Lengend Snippet: Structural and biochemical characterization of ASN007 (A) Molecular structure of ASN007, MW = 473. (B) Dose-response curves of ERK1/2 inhibitors (ASN007 or SCH772894) in a homogeneous time-resolved fluorescence (HTRF)-based ERK1/2 enzymatic activity assay. (C) Kinome tree dendrogram showing the biochemical kinase profiling assay (KinaseProfiler, Eurofiler), which measures the kinase inhibitory activity of ASN007 in a radiometric enzymatic assay in a panel of 335 purified kinases. Hit kinases reported are marked with a red circle and the size of the circle indicates the relative potency of ASN007 for each kinase. ERK1/2 kinases are illustrated by a blue circle. Green dots indicate kinases against which ASN007 does not have significant activity at 1 μM. The dendrogram was generated using the web tool TREESpot, provided by DiscoverX. (D) IC 50 values (nM) for ASN007 against the top 22 kinases, which showed >75% inhibition at 1 μμM, identified from the primary kinome screening. (E) Dose-dependent effect of ASN007 treatment on phosphorylation of ERK1/2 targets. Representative western blot analysis shows inhibition of RSK1 (Ser380) phosphorylation after 4h of ASN007 treatment in a colorectal adenocarcinoma cell line, HT-29. (F) Dose-response curve of ASN007 inhibition of RSK phosphorylation in the human colon cancer HT-29 BRAF V600E mutant cell line, measured by an ELISA test.

    Article Snippet: TREEspot Compound Profile Visualization Tool , DiscoverX , N/A.

    Techniques: Fluorescence, Enzyme Activity Assay, Activity Assay, Enzymatic Assay, Purification, Generated, Inhibition, Phospho-proteomics, Western Blot, Mutagenesis, Enzyme-linked Immunosorbent Assay

    Journal: Cell Reports Medicine

    Article Title: ASN007 is a selective ERK1/2 inhibitor with preferential activity against RAS-and RAF-mutant tumors

    doi: 10.1016/j.xcrm.2021.100350

    Figure Lengend Snippet:

    Article Snippet: TREEspot Compound Profile Visualization Tool , DiscoverX , N/A.

    Techniques: Plasmid Preparation, Recombinant, Proliferation Assay, Software